David Raulet

Esther and Wendy Schekman Chair in Basic Cancer Biology
Professor of Immunology and Pathogenesis
Department of Molecular and Cell Biology
University of California, Berkeley

Raulet's research addresses how developing immune cells, including natural killer (NK) cells, gamma/delta T cells and alpha/beta T cells, assemble and express receptor genes to create a useful repertoire, and how selection processes act on developing immune cells to encourage useful lymphocytes and delete or inactivate dangerous ones. To date, his research has been performed mostly in the mouse system, including studies examining NK cell differentiation from mouse embryonic stem cells. He is now working to establish a system in which human embryonic stem cells can be induced to differentiate into NK cells, gamma/delta T cells or alpha/beta T cells, and to use appropriate culture systems to test models of human lymphocyte differentiation and selection that are based on his findings in animal models.