Jacob Corn

Scientific Director, Innovative Genomics Initiative
Assistant Adjunct Professor of Biochemistry, Biophysics, and Structural Biology
Department of Molecular and Cell Biology
University of California, Berkeley

 

Research in the Corn lab takes a multidisciplinary approach, starting from a foundation of next-generation genome editing technologies such as CRISPR- Cas9, to break through this barrier and build a better understanding of how molecular events shape human biologies, lead to disease, and might be used to generate novel cures. Our approach to this problem is akin to reductionism in the context of biological systems: we introduce minimal perturbations to living human cells, such as making precise mutations at an endogenous locus or altering epigenetic modification at a single site, and measure the resulting phenotypes on multiple levels. The lab works in three broad research areas: technology development to investigate how atomic events impact organismal phenotypes, using biophysics and genome editing to investigate the fundamental bases of cellular signaling with a focus on ubiquitin-mediated processes, and translational research to identify new therapeutic avenues and cure genetic disease.