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Howard Hughes Medical Institute Investigator
REDOX BIOLOGY IN STEM CELLS AND CANCER
Reactive oxygen species (ROS) like hydrogen peroxide are conventionally viewed as phagocytic killing agents of pathogens in immune response or as contributors to oxidative stress and inflammation events associated with aging and diseases ranging from cancer to diabetes to heart disease. However, newly emerging data suggests that hydrogen peroxide can also be an essential component of normal signal transduction cascades. We are studying the signaling/stress dichotomy of hydrogen peroxide and related ROS and their effects on the growth, proliferation, differentiation, and migration of cancer tumor cells and stem cells relevant to anti-tumor chemotherapeutics and regenerative medicine.